NeuroImage Features STAGE Research on Cover of Sept 2020 Issue

The SpinTech team is excited to announce that one of our recent papers made the cover of NeuroImage September 2020 issue!

The paper features the use of our STrategically Acquired Gradient Echo (STAGE) MRI software technology in Parkinson’s research to track changes as the disease progresses. With up to 40% faster scan-time and enhanced image outputs compared to other MRI technologies, researchers were able to optimize the contrast for any tissue changes using two roughly 7-minute scans at just two flip angles (15° and 30°).

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Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson’s disease

Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson’s disease

Diagnosing early stage Parkinson’s disease (PD) is still a clinical challenge. Our goal in this study was to extract the NM complex volume, iron content and volume representing the entire SN, and the N1 sign as potential complementary imaging biomarkers using a single 3D magnetization transfer contrast (MTC) gradient echo sequence and to evaluate their diagnostic performance and clinical correlations in early stage PD.

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Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study

Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study

The purpose of this study was to evaluate the effect of resolution on iron content using quantitative susceptibility mapping (QSM); to verify the consistency of QSM across field strengths and manufacturers in evaluating the iron content of deep gray matter (DGM) of the human brain using subjects from multiple sites; and to establish a susceptibility baseline as a function of age for each DGM structure using both a global and regional iron analysis.

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Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO

Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO

In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce an increase in susceptibility for both arteries and veins to help better reveal the cerebral microvasculature. The purpose of this work was to examine the presence of vascular abnormalities and vascular density in MS lesions using high-resolution susceptibility weighted imaging (SWI).

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