The paper features the use of our STrategically Acquired Gradient Echo (STAGE) MRI software technology in Parkinson’s research to track changes as the disease progresses. With up to 40% faster scan-time and enhanced image outputs compared to other MRI technologies, researchers were able to optimize the contrast for any tissue changes using two roughly 7-minute scans at just two flip angles (15° and 30°).
Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson’s disease
Diagnosing early stage Parkinson’s disease (PD) is still a clinical challenge. Our goal in this study was to extract the NM complex volume, iron content and volume representing the entire SN, and the N1 sign as potential complementary imaging biomarkers using a single 3D magnetization transfer contrast (MTC) gradient echo sequence and to evaluate their diagnostic performance and clinical correlations in early stage PD.